Rai K R
Division of Hematology-Oncology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
Clin Geriatr Med. 1997 May;13(2):245-9.
Chronic lymphocytic leukemia (CLL) is a disease of the elderly with an incidence of about 20 to 30 per 100,000 population in the group aged 70 years or older. Chemotherapy with chlorambucil controls major clinical features of CLL but without prolongation of survival time. Addition of prednisone is necessary when autoimmune complications occur, but its usage in the elderly requires special caution. Fludarabine has better response rates than chlorambucil in treating CLL and has been proved to be an effective salvage therapy in patients previously treated with chlorambucil.
慢性淋巴细胞白血病（CLL）是一种老年疾病，在70岁及以上人群中的发病率约为每10万人20至30例。苯丁酸氮芥化疗可控制CLL的主要临床特征，但不能延长生存时间。当发生自身免疫并发症时，添加泼尼松是必要的，但其在老年人中的使用需要特别谨慎。氟达拉滨在治疗CLL方面比苯丁酸氮芥有更好的缓解率，并且已被证明是对先前接受过苯丁酸氮芥治疗的患者有效的挽救疗法。
