Chrobok V, Simáková E
Department of Otorhinolaryngology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic.
Eur Arch Otorhinolaryngol. 1997;254(1):15-8. doi: 10.1007/BF02630750.
The temporal bones from fetuses with known autosomal trisomy syndromes were examined histopathologically after spontaneous or induced abortions. Fetal ages dated from the 17th to the 24th week of pregnancy. In all, 17 temporal bones from nine fetuses were studied and included seven cases of Down's syndrome and two of Edwards' syndrome. Temporal bones from fetuses with Down's syndrome had more abnormalities of the external and middle ears than of the inner ear. The bones from the fetuses with Edwards' syndrome showed abnormalities of the external or middle ear and retarded development of the inner ear (failed ossification of the otic capsule and unformed organ of Corti).
对已知患有常染色体三体综合征的胎儿，在自然流产或人工流产后对其颞骨进行组织病理学检查。胎儿年龄为妊娠第17至24周。总共研究了9例胎儿的17块颞骨，其中包括7例唐氏综合征和2例爱德华兹综合征。唐氏综合征胎儿的颞骨中外耳和中耳的异常比内耳更多。爱德华兹综合征胎儿的颞骨表现为外耳或中耳异常以及内耳发育迟缓（耳囊骨化失败和柯蒂器未形成）。
