心肌缺血、再灌注与细胞保护
Myocardial ischemia, reperfusion and cytoprotection.
作者信息
Opie L H
机构信息
MRC/UCT Ischaemic Heart Disease Research Unit, Department of Medicine, University of Cape Town, Africa do Sul.
出版信息
Rev Port Cardiol. 1996 Oct;15(10):703-8.
PMID:9115763
Abstract
The hypothesis proposed is that ischemic cell death is a metabolic event as evidenced by ischemic contracture. There is a protective role for glycolytic ATP and for some drugs. There must be enough coronary flow to deliver the glucose. It appears that provision of glucose and restoration of blood flow have complementary benefits. Such combinations need exploration in patients.
摘要
所提出的假说是，缺血性细胞死亡是一种代谢事件，缺血性挛缩就是证据。糖酵解产生的三磷酸腺苷（ATP）以及某些药物具有保护作用。必须有足够的冠状动脉血流来输送葡萄糖。提供葡萄糖和恢复血流似乎具有互补的益处。这种联合疗法需要在患者中进行探索。
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