Scott D B, Littlewood D G, Drummond G B, Buckley P F, Covino B G
Br J Anaesth. 1977 Sep;49(9):917-25. doi: 10.1093/bja/49.9.917.
The cardiovascular changes associated with extradural block were measured in two groups of patients who were also receiving light general anaesthesia. In the first two group (five patients) 2% plain lignocaine 20 ml was used and decreases occurred in mean arterial pressure, cardiac output, stroke volume and peripheral resistance. In the second group (10 patients) 2% lignocaine 20 ml to which adrenaline 1:200,000 had been added was used. Decreases in arterial pressure and peripheral resistance occurred in all patients, but the responses of the cardiac output and heart rate were variable, decreasing in three patients and remaining stable or increasing in seven patients. A high segmental block was presumed to have occurred in those patients who developed bradycardia and a decreased cardiac output. The differences between these studies in anaesthetized patients and those previously reported in conscious volunteers are discussed.
在两组同时接受浅全身麻醉的患者中，测量了与硬膜外阻滞相关的心血管变化。在前两组（五名患者）中，使用了20毫升2%的普通利多卡因，平均动脉压、心输出量、每搏量和外周阻力均下降。在第二组（十名患者）中，使用了加入1:200,000肾上腺素的20毫升2%利多卡因。所有患者的动脉压和外周阻力均下降，但心输出量和心率的反应各不相同，三名患者下降，七名患者保持稳定或增加。推测发生心动过缓和心输出量降低的患者出现了高位节段阻滞。讨论了这些在麻醉患者中的研究与先前在清醒志愿者中报告的研究之间的差异。
