Jacyk W K, Du Bruyn J H, Holm N, Gryffenberg H, Karusseit V O
Department of Dermatology, University of Pretoria, Republic of South Africa.
Br J Dermatol. 1997 Mar;136(3):428-30.
Cladophialophora bantiana (Xylohypha bantiana, Cladosporium trichoides), a dematiaceous fungus, causes mainly infections of the central nervous system. Systemic antifungal therapy is apparently unsuccessful. Extracerebral involvement is uncommon and only few cases have been reported. We describe a 63-year-old patient, a kidney transplant recipient on prolonged prednisone and cyclosporin, who developed a large single lesion on the thigh from which Cladophialophora bantiana was cultured. A 3-month course of itraconazole 200 mg daily resulted in complete healing of the lesion. To the best of our knowledge this is the first report on cutaneous infection with Cladophialophora bantiana in an organ transplant recipient and the first in whom treatment with itraconazole led to resolution.
班替枝孢瓶霉（木生枝孢瓶霉、毛状枝孢）是一种暗色真菌，主要引起中枢神经系统感染。全身抗真菌治疗显然效果不佳。脑外受累情况并不常见，仅有少数病例报道。我们描述了一名63岁的患者，该患者为肾移植受者，长期服用泼尼松和环孢素，其大腿上出现了一个大的单发皮损，从中培养出了班替枝孢瓶霉。每天服用200mg伊曲康唑，疗程为3个月，皮损完全愈合。据我们所知，这是器官移植受者中首例关于班替枝孢瓶霉皮肤感染的报道，也是首例使用伊曲康唑治疗后病情得到缓解的病例。
