Le Pen G, Duterte-Boucher D, Costentin J
Unité de Neuropsychopharmacologie Expérimentale, URA 1969 du CNRS, Institut Fédératif de Recherche Multidisciplinaire sur les Peptides, Faculté de Médecine, Saint Etienne du Rouvray, France.
Neuroreport. 1996 Nov 25;7(18):2839-42. doi: 10.1097/00001756-199611250-00005.
The rewarding and locomotor effects of the specific dopamine uptake inhibitor GBR12783 (2.5-20 mg kg-1, i.p.) were compared with those of cocaine. For both drugs, all doses produced a conditioned place preference (CPP), even the dose of 2.5 mg kg-1, which did not modify the locomotor activity. Despite an equivalent locomotor stimulation, the magnitude of CPP induced by cocaine (10 mg kg-1) was greater than that induced by the same dose of GBR12783. This confirms the involvement of dopamine uptake inhibition in reward, but underlines differences in relative efficacies in rewarding and motor effects of both drugs and suggests that these two properties are, at least in part, separable anatomically or functionally.
将特定多巴胺摄取抑制剂GBR12783（2.5 - 20毫克/千克，腹腔注射）的奖赏和运动效应与可卡因的效应进行了比较。对于这两种药物，所有剂量均产生了条件性位置偏爱（CPP），即使是2.5毫克/千克的剂量，该剂量并未改变运动活性。尽管运动刺激相当，但可卡因（10毫克/千克）诱导的CPP幅度大于相同剂量GBR12783诱导的幅度。这证实了多巴胺摄取抑制参与奖赏，但强调了两种药物在奖赏和运动效应方面相对效力的差异，并表明这两种特性至少在解剖学或功能上部分是可分离的。
