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神经生长因子信号传导的基因激活途径：一篇综述

Gene activation pathways of nerve growth factor signaling: a minireview.

作者信息

Szeberényi J

机构信息

Department of Biology, University Medical School of Pécs, Hungary.

出版信息

Neurobiology (Bp). 1996;4(1-2):1-11.

PMID:9116683
Abstract

PC12 rat pheochromocytoma cells provide an excellent model system to study the mechanism of nerve growth factor-induced neuronal differentiation. PC12 cells expressing a dominant inhibitory Ras protein are being used to elucidate the role of this key signal transduction protein in gene activation events accompanying morphological differentiation of these cells. The possible involvement of Ras-dependent protein phosphorylation cascades in NGF-induced gene expression are discussed in this paper.

摘要

PC12大鼠嗜铬细胞瘤细胞为研究神经生长因子诱导的神经元分化机制提供了一个出色的模型系统。表达显性抑制性Ras蛋白的PC12细胞正被用于阐明这种关键信号转导蛋白在这些细胞形态分化伴随的基因激活事件中的作用。本文讨论了Ras依赖性蛋白磷酸化级联反应在神经生长因子诱导的基因表达中的可能参与情况。

相似文献

1
Gene activation pathways of nerve growth factor signaling: a minireview.神经生长因子信号传导的基因激活途径：一篇综述
Neurobiology (Bp). 1996;4(1-2):1-11.
2
Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells.多种信号传导途径调节PC12细胞中全局分化特异性基因的表达。
J Cell Physiol. 2004 Dec;201(3):459-69. doi: 10.1002/jcp.20087.
3
Sustained activation of M-Ras induced by nerve growth factor is essential for neuronal differentiation of PC12 cells.神经生长因子诱导的M-Ras持续激活对PC12细胞的神经元分化至关重要。
Genes Cells. 2006 Sep;11(9):1097-113. doi: 10.1111/j.1365-2443.2006.01002.x.
4
Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells.神经生长因子和表皮生长因子刺激PC12细胞中的簇集蛋白基因表达。
Biochem J. 1999 May 1;339 ( Pt 3)(Pt 3):759-66.
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Sustained activation of extracellular signal-regulated kinase by nerve growth factor regulates c-fos protein stabilization and transactivation in PC12 cells.神经生长因子对细胞外信号调节激酶的持续激活可调节PC12细胞中c-fos蛋白的稳定性和反式激活。
J Neurochem. 2006 Dec;99(6):1480-93. doi: 10.1111/j.1471-4159.2006.04250.x.
6
Influence of Ras and retinoic acid on nerve growth factor induction of transin gene expression in PC12 cells.Ras和视黄酸对PC12细胞中神经生长因子诱导的转胶酶基因表达的影响。
Oncogene. 1997 Apr 10;14(14):1687-96. doi: 10.1038/sj.onc.1200997.
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c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation.c-Myc通过阻断c-Jun的上调来抑制Ras介导的嗜铬细胞瘤细胞分化。
Mol Cancer Res. 2008 Feb;6(2):325-39. doi: 10.1158/1541-7786.MCR-07-0180.
8
The ras suppressor, RSU-1, enhances nerve growth factor-induced differentiation of PC12 cells and induces p21CIP expression.ras抑制因子RSU-1可增强神经生长因子诱导的PC12细胞分化并诱导p21CIP表达。
Cell Growth Differ. 1999 Aug;10(8):555-64.
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Induction of neurite outgrowth in PC12 cells by gamma-lactam-related compounds via Ras-MAP kinase signaling pathway independent mechanism.γ-内酰胺相关化合物通过独立于Ras-MAP激酶信号通路的机制诱导PC12细胞神经突生长。
Exp Cell Res. 1997 Aug 1;234(2):233-9. doi: 10.1006/excr.1997.3615.
10
Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells.神经生长因子通过PC12细胞中两个不同的信号级联反应诱导存活和分化。
Oncogene. 1999 Mar 25;18(12):2055-68. doi: 10.1038/sj.onc.1202524.

引用本文的文献

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Protein phosphatase magnesium dependent 1A (PPM1A) plays a role in the differentiation and survival processes of nerve cells.蛋白磷酸酶镁依赖性 1A（PPM1A）在神经细胞的分化和存活过程中发挥作用。
PLoS One. 2012;7(2):e32438. doi: 10.1371/journal.pone.0032438. Epub 2012 Feb 27.
2
Colostrinin-driven neurite outgrowth requires p53 activation in PC12 cells.初乳素驱动的神经突生长需要PC12细胞中的p53激活。
Cell Mol Neurobiol. 2005 Nov;25(7):1123-39. doi: 10.1007/s10571-005-8222-6.
3
Development of an ischemic tolerance model in a PC12 cell line.
在PC12细胞系中建立缺血耐受模型。
J Cereb Blood Flow Metab. 2005 Feb;25(2):154-162. doi: 10.1038/sj.jcbfm.9600003.
4
The growth-inhibitory Ndrg1 gene is a Myc negative target in human neuroblastomas and other cell types with overexpressed N- or c-myc.生长抑制性Ndrg1基因是人类神经母细胞瘤以及其他N-或c-myc过度表达的细胞类型中的Myc负调控靶标。
Mol Cell Biochem. 2003 Aug;250(1-2):91-105. doi: 10.1023/a:1024918328162.
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Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling.孕酮和醋酸甲羟孕酮（安宫黄体酮）对细胞核丝裂原活化蛋白激酶信号传导的不同影响。
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10506-11. doi: 10.1073/pnas.1334098100. Epub 2003 Aug 18.
6
Ovarian hormones elicit phosphorylation of Akt and extracellular-signal regulated kinase in explants of the cerebral cortex.卵巢激素可引起大脑皮质外植体中Akt和细胞外信号调节激酶的磷酸化。
Endocrine. 2001 Apr;14(3):407-15. doi: 10.1385/ENDO:14:3:407.
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The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells.转录共抑制因子NAB2抑制神经生长因子诱导的PC12细胞分化。
J Cell Biol. 1998 Aug 24;142(4):1075-82. doi: 10.1083/jcb.142.4.1075.