抗脂解剂对异丙肾上腺素诱导的大鼠心肌坏死的影响。
The effect of anti-lipolytic agents on isoprenaline-induced myocardial necrosis in the rat.
作者信息
Woolf N, Steen E, Rosen D, Trickey R, Long P, Miller A L, Rowles P M
出版信息
Br J Exp Pathol. 1977 Aug;58(4):438-43.
The effect of inhibiting isoprenaline-induced lipolysis on the degree of damage produced in the rat myocardium by this amine has been investigated by pre-dosing rats with the anti-lipolytic agent 5-fluoro-nicotinic acid. The degree of myocardial necrosis produced in animals given isoprenaline alone and those pre-dosed with the anti-lipolytic agent was measured by the use of an automated flying spot microscope to show absence of formazan from dead muscle fibres in sections treated to demonstrate succinic dehydrogenase. The use of the anti-lipolitic considerably reduced the degree of myocardial damage produced by a standard dose of isoprenaline bitartrate. This was associated with an inhibition of the post-isoprenaline rise in plasma free fatty acid levels. The results are discussed in relation to the possible protective roles of the lowering of plasma free fatty acid levels and inhibition of the adenyl cyclase system at the plasma membrane of the myocardial cell produced directly by the anti-lipolytic.
通过给大鼠预先服用抗脂解剂5-氟烟酸，研究了抑制异丙肾上腺素诱导的脂解作用对该胺类物质所致大鼠心肌损伤程度的影响。单独给予异丙肾上腺素的动物以及预先服用抗脂解剂的动物的心肌坏死程度，通过使用自动飞点显微镜进行测量，以显示在经处理以显示琥珀酸脱氢酶的切片中，死亡肌纤维中不存在甲臜。使用抗脂解剂可显著降低标准剂量的重酒石酸异丙肾上腺素所致的心肌损伤程度。这与抑制异丙肾上腺素作用后血浆游离脂肪酸水平的升高有关。结合抗脂解剂直接降低血浆游离脂肪酸水平以及抑制心肌细胞质膜上的腺苷酸环化酶系统可能起到的保护作用，对结果进行了讨论。
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