Antoine J M, Loumaye E, Alvarez S, Merviel P, Cornet D, Mandelbaum J, Salat-Baroux J
Service de Gynécologie-Obstétrique, Hôpital Tenon, Paris.
Contracept Fertil Sex. 1997 Feb;25(2):141-6.
The production of recombinant gonadotropins is independent of urine collection. They have a high specific activity and a better batch to batch consistency than urinary gonadotropins. In our IVF programme 62 normo-ovulatory patients less than 38 years old, with tubal or idiopathic infertility and normal sperm, were treated by r-FSH and randomized into four groups : with or without LHRH agonist, step-up or step-down stimulation. The overall results were higher in the agonist groups, but did not reveal any significant difference between step-up and step-down stimulation.
重组促性腺激素的生产不依赖于尿液采集。它们具有高比活性，并且与尿促性腺激素相比，批次间一致性更好。在我们的体外受精计划中，62名年龄小于38岁、患有输卵管性或特发性不孕症且精子正常的排卵正常患者，接受了重组促卵泡素（r-FSH）治疗，并随机分为四组：使用或不使用促黄体生成素释放激素（LHRH）激动剂，递增或递减刺激。激动剂组的总体结果更高，但递增和递减刺激之间未显示出任何显著差异。
