Mentges B, Buess G, Effinger G, Manncke K, Becker H D
Department of General Surgery of the Eberhard Karls University Hospital, Tübingen, Germany.
Br J Surg. 1997 Mar;84(3):348-51.
Local therapy of early rectal carcinoma has become an alternative to the classical radical operation which has a higher morbidity and mortality rate.
Rectal carcinoma was treated by transanal endoscopic microsurgery (TEM) in 113 patients. The indications for the procedure were pT1 low-risk tumour, advanced tumour in high-risk patients, and patients who refused more radical surgery based on oncological guidelines.
Sixty-four patients had pT1, 33 pT2 and 16 pT3 tumours. No patient died as a result of TEM. The rate of complications which needed operative intervention was 7 per cent. So far, two of the patients treated by local resection of pT1 low-risk tumours have had a recurrence. In both cases, a secondary procedure was possible with curative intent.
Patients with pT1 rectal tumours represent a suitable group for local treatment because of the acceptability of the procedure and the low recurrence rate.
早期直肠癌的局部治疗已成为传统根治性手术的替代方案,传统根治性手术的发病率和死亡率较高。
113例直肠癌患者接受了经肛门内镜显微手术(TEM)治疗。该手术的适应症为pT1低风险肿瘤、高危患者的进展期肿瘤以及根据肿瘤学指南拒绝更根治性手术的患者。
64例患者为pT1肿瘤,33例为pT2肿瘤,16例为pT3肿瘤。没有患者因TEM死亡。需要手术干预的并发症发生率为7%。到目前为止,2例接受pT1低风险肿瘤局部切除治疗的患者出现了复发。在这两种情况下,二次手术都有可能达到治愈目的。
pT1直肠癌患者因其手术的可接受性和低复发率,是局部治疗的合适人群。