Wu G, Hallin R G, Ekedahl R
Department of Medical Laboratory Science and Technology, Huddinge University Hospital, Karolinska Institute, Sweden.
Brain Res. 1996 Dec 2;742(1-2):225-38. doi: 10.1016/s0006-8993(96)01015-3.
Percutaneous microneurography was performed with concentric needle electrodes to record neural activity from myelinated fibres in human peripheral nerves. Template matching techniques were used together with interspike interval analysis and studies on functional class, receptive field characteristics, conduction velocities and other single fibre properties to classify single units. Sometimes the same fibres exhibited different action potentials at the same time. The potentials had some common features, but differed either in their waveform types or only in duration. There was a correlation between the occurrence of the different potential shapes and firing frequency of the studied unit. The outcome of the studies suggested that there was a common denominator which could explain the observations. Most likely, momentary fluctuations in excitability of the myelinated fibres occurring during the relative refractory period or the supernormal period were responsible for the variations in complexity of the studied units due to a partial block of fibre propagation probably caused by the recording electrode. Thus, action potentials deriving from the same axon may not always have the same shapes. Methods for unit classification, such as template matching, are discussed in the light of our findings.
采用同心针电极进行经皮微神经ography，以记录人类周围神经中髓鞘纤维的神经活动。模板匹配技术与峰间期分析以及功能类别、感受野特征、传导速度和其他单纤维特性的研究一起用于对单个单元进行分类。有时，同一纤维会同时表现出不同的动作电位。这些电位有一些共同特征，但在波形类型上或仅在持续时间上有所不同。所研究单元的不同电位形状的出现与放电频率之间存在相关性。研究结果表明，存在一个共同的因素可以解释这些观察结果。最有可能的是，在相对不应期或超常期期间髓鞘纤维兴奋性的瞬间波动是由于记录电极可能导致的纤维传播部分阻滞，从而导致所研究单元复杂性变化的原因。因此，源自同一轴突的动作电位可能并不总是具有相同的形状。根据我们的研究结果，讨论了诸如模板匹配等单元分类方法。
