Mackay K B, Bailey S J, King P D, Patel S, Hamilton T C, Campbell C A
Department of Neurology Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex.
Neurodegeneration. 1996 Dec;5(4):319-23. doi: 10.1006/neur.1996.0043.
The neuroprotective effects of recombinant neutrophil inhibitory factor (NIF) have been assessed with temporary (2 h) middle cerebral artery (MCA) occlusion in the rat using the intraluminal suture technique. Administration of NIF (1.5 mg/kg, i.v.) immediately after the onset of reperfusion and at 4 and 6 h post-MCA occlusion significantly reduced both hemispheric infarct volume (P < 0.001) and brain swelling (P < 0.001), and improved neurological outcome (P < 0.02) when assessed at 24 h. These results demonstrated the marked neuroprotective efficacy of NIF in a rat model of transient focal cerebral ischaemia.
利用管腔内缝合技术，在大鼠大脑中动脉（MCA）进行2小时短暂闭塞，以此评估重组中性粒细胞抑制因子（NIF）的神经保护作用。在再灌注开始时以及MCA闭塞后4小时和6小时静脉注射NIF（1.5毫克/千克），显著减少了半球梗死体积（P<0.001）和脑肿胀（P<0.001），并且在24小时评估时改善了神经功能结局（P<0.02）。这些结果证明了NIF在短暂性局灶性脑缺血大鼠模型中具有显著的神经保护功效。
