Rapoport S I, Hatanpää K, Brady D R, Chandrasekaran K
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Neurodegeneration. 1996 Dec;5(4):473-6. doi: 10.1006/neur.1996.0065.
Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.
通过活体正电子发射断层扫描测量发现，阿尔茨海默病早期大脑葡萄糖利用率降低，这反映出神经元线粒体内氧化磷酸化基因表达可能存在可逆性下调。当神经元能量需求因突触功能障碍或丧失而首次降低时，可能会发生这种下调。
