Green C
Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.
Contact Dermatitis. 1996 Dec;35(6):331-3. doi: 10.1111/j.1600-0536.1996.tb02412.x.
The purpose of the study was to assess the effect of topical corticosteroid on the patch test response in patients with known positive allergens and also to study any effect on the irritant response. In Study 1, 10 patients with known positive allergens had their backs pre-treated 2 x daily for 3 days with either betamethasone dipropionate 0.05% or the equivalent ointment base. On day 4, previous known allergens and dilutions of sodium lauryl sulfate (5% and 10%) as an irritant were applied to each side of the back. In Study 2 (4 patients), a 1:4 dilution of betamethasone dipropionate was substituted for the full-strength preparation. Betamethasone dipropionate 0.05% caused total or partial suppression of the allergic reaction in 8 of 10 cases. The 1:4 dilution caused partial suppression in 3 cases. The irritant reaction was totally suppressed by betamethasone dipropionate in 1 of 10 cases and partially suppressed in 7 of 10. The 1:4 dilution decreased the intensity of the irritant reaction in 3 of 4 cases. The relevance of these results to clinical practice is discussed.
本研究的目的是评估外用皮质类固醇对已知过敏原阳性患者斑贴试验反应的影响，并研究其对刺激反应的任何影响。在研究1中，10名已知过敏原阳性的患者背部，每天预先用0.05%丙酸倍氯米松或等量的软膏基质处理2次，持续3天。在第4天，将先前已知的过敏原和作为刺激物的十二烷基硫酸钠稀释液（5%和10%）涂于背部两侧。在研究2（4名患者）中，用1:4稀释的丙酸倍氯米松替代全强度制剂。0.05%丙酸倍氯米松在10例中有8例导致过敏反应完全或部分受到抑制。1:4稀释液在3例中导致部分抑制。在10例中，丙酸倍氯米松在1例中完全抑制了刺激反应，在7例中部分抑制了刺激反应。1:4稀释液在4例中有3例降低了刺激反应的强度。讨论了这些结果与临床实践的相关性。
