Termination of 2nd and 3rd trimester pregnancies with mifepristone and misoprostol.
作者信息
Jannet D, Aflak N, Abankwa A, Carbonne B, Marpeau L, Milliez J
机构信息
Department of Obstetrics and Gynecology, Saint-Antoine Hospital, Paris, France.
出版信息
Eur J Obstet Gynecol Reprod Biol. 1996 Dec 27;70(2):159-63. doi: 10.1016/s0301-2115(95)02593-6.
OBJECTIVE
The purpose of this study was to evaluate our use of the association of mifepristone and misoprostol for terminating second and third trimester pregnancies.
STUDY DESIGN
One hundred and six patients undergoing termination of pregnancy between January 1993 and June 1995 in our center were studied. Each patient received 600 mg of mifepristone followed 24 h later by 400 microgrammes of misoprostol every 6 h.
RESULTS
The average interval from the first administration of misoprostol to expulsion was 12.5 +/- 7.5 h (interval markedly decreased to 9.6 +/- 6.3 h in cases of intrauterine fetal death).
CONCLUSION
The efficacy of the association of mifepristone and misoprostol is comparable with that of current regimens with grealer ease of utilization and at a much lower cost.
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