Jannet D, Aflak N, Abankwa A, Carbonne B, Marpeau L, Milliez J
Department of Obstetrics and Gynecology, Saint-Antoine Hospital, Paris, France.
Eur J Obstet Gynecol Reprod Biol. 1996 Dec 27;70(2):159-63. doi: 10.1016/s0301-2115(95)02593-6.
The purpose of this study was to evaluate our use of the association of mifepristone and misoprostol for terminating second and third trimester pregnancies.
One hundred and six patients undergoing termination of pregnancy between January 1993 and June 1995 in our center were studied. Each patient received 600 mg of mifepristone followed 24 h later by 400 microgrammes of misoprostol every 6 h.
The average interval from the first administration of misoprostol to expulsion was 12.5 +/- 7.5 h (interval markedly decreased to 9.6 +/- 6.3 h in cases of intrauterine fetal death).
The efficacy of the association of mifepristone and misoprostol is comparable with that of current regimens with grealer ease of utilization and at a much lower cost.
