Meuwissen R L, Meerts I, Hoovers J M, Leschot N J, Heyting C
Department of Genetics, Agricultural University, Wageningen, The Netherlands.
Genomics. 1997 Feb 1;39(3):377-84. doi: 10.1006/geno.1996.4373.
Synaptonemal complexes (SCs) are structures that are formed between homologous chromosomes (homologs) during meiotic prophase. They consist of two proteinaceous axes, one along each homolog, that are connected along their length by numerous transverse filaments (TFs). The cDNA encoding one major component of TFs of SCs of the rat, rnSCP1, has recently been isolated and characterized. In this paper we describe the isolation and characterization of the cDNA encoding the human protein homologous to rnSCP1, hsSCP1. hsSCP1 and rnSCP1 have 75% amino acid identity. The most prominent structural features and amino acid sequence motifs of rnSCP1 have been conserved in hsSCP1. Most probably, hsSCP1 is functionally homologous to rnSCP1. The hsSCP1 gene was assigned to human chromosome 1p12-p13 by fluorescence in situ hybridization.
联会复合体（SCs）是在减数分裂前期同源染色体（同源物）之间形成的结构。它们由两条蛋白质轴组成，每条同源物上一条，这两条轴沿其长度通过许多横向细丝（TFs）相连。编码大鼠SCs的TFs一种主要成分的cDNA，即rnSCP1，最近已被分离和鉴定。在本文中，我们描述了编码与rnSCP1同源的人类蛋白质hsSCP1的cDNA的分离和鉴定。hsSCP1和rnSCP1具有75%的氨基酸同一性。rnSCP1最突出的结构特征和氨基酸序列基序在hsSCP1中得以保留。很可能，hsSCP1在功能上与rnSCP1同源。通过荧光原位杂交将hsSCP1基因定位于人类染色体1p12 - p13。
