Stoodley M A, Brown S A, Brown C J, Jones N R
Department of Surgery (Neurosurgery), University of Adelaide, South Australia.
J Neurosurg. 1997 Apr;86(4):686-93. doi: 10.3171/jns.1997.86.4.0686.
The impetus for the enlargement of syringes is unknown. The authors hypothesize that there is a flow of cerebrospinal fluid (CSF) from perivascular spaces into the central canal and that the flow is driven by arterial pulsations. Using horseradish peroxidase as a tracer, the CSF flow was studied in normal sheep, in sheep with damped arterial pulsations, and in sheep with lowered spinal subarachnoid pressure. The CSF flow from perivascular spaces into the central canal was demonstrated in the normal sheep, and two patterns of flow were identified: 1) from perivascular spaces in the central gray matter; and 2) from perivascular spaces in the ventral white commissure. Flow into the central canal was also observed in the sheep with lowered spinal subarachnoid pressure, but not in those with reduced arterial pulse pressure. This study provides evidence that CSF flow from perivascular spaces into the central canal is dependent on arterial pulsations. Arterial pulsation-driven CSF flow may be the impetus for the expansion of syringes.
尚不清楚注射器扩大的诱因。作者推测，存在脑脊液（CSF）从血管周围间隙流入中央管的情况，且这种流动是由动脉搏动驱动的。使用辣根过氧化物酶作为示踪剂，在正常绵羊、动脉搏动减弱的绵羊以及脊髓蛛网膜下腔压力降低的绵羊中研究了脑脊液流动情况。在正常绵羊中证实了脑脊液从血管周围间隙流入中央管，并识别出两种流动模式：1）从中央灰质的血管周围间隙；2）从腹侧白质连合的血管周围间隙。在脊髓蛛网膜下腔压力降低的绵羊中也观察到了流入中央管的情况，但在动脉脉压降低的绵羊中未观察到。本研究提供了证据表明脑脊液从血管周围间隙流入中央管依赖于动脉搏动。动脉搏动驱动的脑脊液流动可能是注射器扩大的诱因。
