Tálosi G, Streitman K, Surányi A, Pintér S, Horváth I, Mulugeta Z
Department of Pediatrics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
J Perinat Med. 1996;24(6):693-7. doi: 10.1515/jpme.1996.24.6.693.
Sonographic examinations as well as blood and urine chemistry tests were carried out in 4 neonates (3 mature, 1 premature) with transient renal failure, who were suffering from the effects of neonatal asphyxia of varying etiology. The first ultrasound examinations of the kidneys were performed within 24 hours after the hypoxic event. Simultaneously, blood and urine tests for parameters of renal function and purine metabolites were also carried out. Transient insufficiency of renal function could be detected in all cases with hyper-uricemia and hyper-uricosuria with no hypercalciuria. Ultrasonographic examinations showed hyper-echogenicity of the renal pyramids in all of the cases and hyper-reflectivity of the renal cortex in cases 2 and 4. In 3 cases, hyper-echogenicity appeared within 24 hours and disappeared in a short time, while in case 3 it could be detected from day 4 until day 14. These findings demonstrate, that the neonatal kidney is very sensitive to hypoxia and that hypoxic renal failure is accompanied by hyper-echogenicity of the kidneys. Uric acid is a possible cause of the renal hyper-echogenicity.
对4例（3例足月儿，1例早产儿）患有不同病因新生儿窒息所致短暂性肾衰竭的新生儿进行了超声检查以及血液和尿液化学检测。在缺氧事件发生后24小时内对肾脏进行了首次超声检查。同时，还进行了血液和尿液中肾功能及嘌呤代谢产物参数的检测。所有病例均检测到肾功能短暂性不全，伴有高尿酸血症和高尿酸尿症，但无高钙尿症。超声检查显示，所有病例的肾锥体均为高回声，病例2和4的肾皮质为高回声。3例在24小时内出现高回声并在短时间内消失，而病例3从第4天至第14天可检测到高回声。这些发现表明，新生儿肾脏对缺氧非常敏感，缺氧性肾衰竭伴有肾脏高回声。尿酸可能是肾脏高回声的原因。
