激进边缘将顶端外胚层嵴定位在脊椎动物肢体的背腹边界处。

Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb.

作者信息

Rodriguez-Esteban C, Schwabe J W, De La Peña J, Foys B, Eshelman B, Izpisúa Belmonte J C

机构信息

Gene Expression Laboratory, The Salk Institute, La Jolla, California 92037, USA.

出版信息

Nature. 1997 Mar 27;386(6623):360-6. doi: 10.1038/386360a0.

DOI:10.1038/386360a0

PMID:9121551

Abstract

Vertebrate limb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the previous establishment of the dorsoventral limb axis. Radical fringe is expressed in the dorsal ectoderm before the ridge appears, and is repressed by Engrailed-1, which is expressed in the ventral ectoderm. Misexpression of these genes indicates that a ridge is formed wherever there is a boundary between cells expressing and not expressing Radical fringe. Thus, as in Drosophila, Radical fringe positions the ridge at the dorsoventral limb boundary.

摘要

脊椎动物肢体的生长需要一种名为顶端外胚层嵴的结构，其形成发生在背腹肢体轴先前确立之后。在嵴出现之前，Radical fringe基因在背侧外胚层中表达，并受到在腹侧外胚层中表达的Engrailed-1基因的抑制。这些基因的错误表达表明，在表达和不表达Radical fringe基因的细胞之间的边界处都会形成嵴。因此，与果蝇的情况一样，Radical fringe基因将嵴定位在肢体的背腹边界处。