肢体芽外胚层中Radical边缘的表达调节顶端外胚层嵴的形成。

Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation.

作者信息

Laufer E, Dahn R, Orozco O E, Yeo C Y, Pisenti J, Henrique D, Abbott U K, Fallon J F, Tabin C

机构信息

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Nature. 1997 Mar 27;386(6623):366-73. doi: 10.1038/386366a0.

DOI:10.1038/386366a0

PMID:9121552

Abstract

The apical ectodermal ridge of the vertebrate limb bud lies at the junction of the dorsal and ventral ectoderm and directs patterning of the growing limb. Its formation is directed by the boundary between cells that do and cells that do not express the gene Radical fringe. This is similar to the establishment of the margin cells at the Drosophila wing dorsoventral border by fringe. Radical fringe expression in chick-limb dorsal ectoderm is established in part through repression by Engrailed-1 in the ventral ectoderm.

摘要

脊椎动物肢体芽的顶端外胚层嵴位于背侧和腹侧外胚层的交界处，指导着生长中肢体的模式形成。它的形成由表达基因Radical fringe的细胞和不表达该基因的细胞之间的边界所引导。这类似于果蝇翅膀背腹边界处由fringe建立边缘细胞。鸡肢体背侧外胚层中Radical fringe的表达部分是通过腹侧外胚层中Engrailed-1的抑制作用而建立的。