Thieffry D
Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode Saint Genèse, Belgique.
Hist Philos Life Sci. 1996;18(2):163-93.
This article concerns the elaboration of epigenetic models for differentiation. I discuss how results and conclusions arising from studies of prokaryotes were extrapolated to explain differentiation during metazoan development. In this respect, I focus on the presentation of a multi-stable biochemical model by Delbrück in 1949, and on a series of works dealing with enzyme adaptation in Escherichia coli that culminated in Jacob and Monod's operon model. These influential contributions are discussed in the context of debates on nuclear versus cytoplasmic heredity, on the regulation of gene expression, as well as on the mechanisms at the basis of cell differentiation.
本文关注用于分化的表观遗传模型的阐述。我将探讨原核生物研究得出的结果和结论是如何被外推以解释后生动物发育过程中的分化现象。在这方面，我将重点介绍1949年德尔布吕克提出的多稳态生化模型，以及一系列关于大肠杆菌中酶适应性的研究工作，这些研究最终形成了雅各布和莫诺的操纵子模型。这些有影响力的贡献将在关于核遗传与细胞质遗传、基因表达调控以及细胞分化基础机制的争论背景下进行讨论。
