Paul T, Bökenkamp R, Mahnert B, Trappe H J
Department of Pediatric Cardiology, Hannover Medical School, Germany.
Am Heart J. 1997 Apr;133(4):436-40. doi: 10.1016/s0002-8703(97)70185-6.
Radiofrequency current (500 kHz) was delivered by temperature guidance (75 degrees C) over a 30-second period in 10 young piglets with a steerable 6F electrode catheter equipped with a thermistor at the 4 mm tip electrode. Lesions were created at the right atrial aspect of the tricuspid valve anulus, at the left ventricular myocardium under the lateral mitral valve anulus, and at the left ventricular apex. After 48 hours, five animals were randomly sacrificed. Lesions in the five animals appeared as transmural gray-white coagulation necrosis. Lymphocytic infiltration around the right atrial lesions extended into the layers of the right coronary artery in four of five animals. After 6 months, lesions consisted of compact fibrous tissue in the remaining five animals. Right atrial lesions extended to the layers of the right coronary artery in four of five pigs. In two animals the lumen of the right coronary artery was narrowed because of intimal thickening by 25% and 40%, respectively. No increase in the lesion size was observed with the growth of the animals. Effects on the right coronary artery as a late sequela after radiofrequency current application may also be possible in human beings and should be considered when radiofrequency current ablation procedures are proposed in infants and young children.
在10只幼猪中，使用配备有位于4毫米尖端电极处热敏电阻的可操纵6F电极导管，通过温度引导（75摄氏度）在30秒内施加射频电流（500千赫兹）。在三尖瓣环右心房侧、二尖瓣环外侧下方的左心室心肌以及左心室心尖处制造损伤。48小时后，随机处死5只动物。这5只动物的损伤表现为透壁性灰白色凝固性坏死。5只动物中有4只动物右心房损伤周围的淋巴细胞浸润延伸至右冠状动脉各层。6个月后，其余5只动物的损伤由致密纤维组织构成。5只猪中有4只猪的右心房损伤延伸至右冠状动脉各层。在2只动物中，右冠状动脉管腔因内膜增厚分别变窄了25%和40%。未观察到随着动物生长损伤大小增加。射频电流施加后作为晚期后遗症对右冠状动脉的影响在人类中也可能出现，在对婴幼儿提议进行射频电流消融手术时应予以考虑。
