Shellenberger M K, Young D N, Levine M S
Brain Res Bull. 1977 Jul-Aug;2(4):273-7. doi: 10.1016/0361-9230(77)90083-1.
Single units were recorded bilaterally from the caudate nuclei of cats before and after 50 microliter injections of either Merlis solution or L-DOPA (200 microgram) dissolved in Merlis into the left lateral cerebral ventricle. After injection of L-DOPA, but not Merlis solution, there was a period of unit silence in both caudates with an onset of about 10 min and a duration of 30-50 min. This period of caudate silence was coincident with a significant reduction of systolic blood pressure and heart rate. Upon resumption of unit firing in caudate, it was found that the interspike intervals on the contralateral side were markedly increased from 30 min-2 hr postinjection while there was no change on the side of injection. The similarity of this response to that following lesions which interrupt the caudate to thalamus pathway unilaterally was discussed. It is suggested that L-DOPA injection may produce this lesion-like effect by altering the firing of caudate output neurons.
在向猫的左侧侧脑室注射50微升Merlis溶液或溶于Merlis的L-多巴（200微克）之前和之后，从双侧尾状核记录单个神经元活动。注射L-多巴后，而非Merlis溶液后，双侧尾状核均出现一段时间的神经元静息，开始时间约为10分钟，持续时间为30 - 50分钟。这段尾状核静息期与收缩压和心率的显著降低同时出现。当尾状核恢复神经元放电时，发现注射后30分钟至2小时，对侧的峰间期明显延长，而注射侧无变化。讨论了这种反应与单侧中断尾状核至丘脑通路的损伤后反应的相似性。提示注射L-多巴可能通过改变尾状核输出神经元的放电而产生这种类似损伤的效应。
