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复杂牛VNTR基因座处的小卫星和微卫星长度变异

Minisatellite and microsatellite length variation at a complex bovine VNTR locus.

作者信息

Nave A, Kashi Y, Soller M

机构信息

Department of Genetics, Alexander Silberman Life Sciences Institute, Hebrew University of Jerusalem, Israel.

出版信息

Anim Genet. 1997 Feb;28(1):52-4. doi: 10.1111/j.1365-2052.1997.00069.x.

Abstract

Length variation at the BTGL1 variable number of tandem repeat (VNTR) locus, which includes both minisatellite and microsatellite motifs, was examined in a wide sample of cattle. A total of 22 alleles were uncovered. The distribution of allele size variation implicated mechanisms involving both minisatellite and microsatellite sequences. This was confirmed by direct sequences of two alleles. Differences between the two alleles involved repeat number variation of microsatellite motifs and a complex event involving the minisatellite motif, but point mutations were not observed.

摘要

在广泛的牛样本中,对包含小卫星和微卫星基序的BTGL1可变串联重复序列(VNTR)位点的长度变异进行了检测。共发现了22个等位基因。等位基因大小变异的分布暗示了涉及小卫星和微卫星序列的机制。这通过两个等位基因的直接测序得到了证实。两个等位基因之间的差异涉及微卫星基序的重复数变异以及一个涉及小卫星基序的复杂事件,但未观察到点突变。

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