Dupuis O, Bourhis J, Attal P, Lusinchi A, Julieron M, Domenge C, Marandas P, Schwaab G, Bobin S, Luboinski B, Wibault P, Eschwege F
Département de Radiothérapie, Institut Gustave Roussy, Villejuif.
Ann Otolaryngol Chir Cervicofac. 1996;113(5):251-60.
From 1992 to 1993, 46 patients with very locally advanced (74% T4) head and neck carcinomas and extensive cervical involvement (82% N2-3) were treated at the Institute Gustave Roussy with a very accelerated radiotherapy regimen: 62 Gy in three weeks with two daily 1.75 Gy fractions. Early mucosal reactions were severe but manageable in this population of patients with frequent alteration of initial performance status. Nearly every patient experienced a grade 3 or 4 (WHO) mucositis and 80% required tube feeding. Follow-up is not sufficient to draw firm conclusion about late reactions but they do not seem different from those induced by conventional radiotherapy. The overall 2-year survival rate of 49.4% and loco-regional control rate of 67% seem superior to the results of conventional radiotherapy for such advanced tumors. These results have led to a multi-center randomized controlled trial comparing this regimen of accelerated radiotherapy with conventional fractionated radiotherapy.
1992年至1993年期间，古斯塔夫·鲁西研究所采用一种加速放疗方案对46例极局部晚期（74%为T4期）头颈癌且伴有广泛颈部受累（82%为N2-3期）的患者进行了治疗：三周内给予62 Gy，每日分两次给予，每次1.75 Gy。在这群初始身体状况经常改变的患者中，早期黏膜反应严重但可控。几乎每位患者都出现了3级或4级（世界卫生组织）黏膜炎，80%的患者需要鼻饲。随访时间不足，无法就晚期反应得出确凿结论，但它们似乎与传统放疗引起的反应并无不同。对于此类晚期肿瘤，49.4%的2年总生存率和67%的局部区域控制率似乎优于传统放疗的结果。这些结果促使开展了一项多中心随机对照试验，将这种加速放疗方案与传统分割放疗进行比较。
