Higashi K, Ishikawa T, Ito T, Yonemura A, Shige H, Nakamura H
First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Biochem Biophys Res Commun. 1997 Mar 27;232(3):728-30. doi: 10.1006/bbrc.1997.6339.
Mutation frequencies in the beta 3-adrenergic receptor gene were measured in 83 CAD patients and 107 controls (all Japanese nationals) and the mutation incidence in the two groups was compared. The relationship between characteristics of lipid and glucose metabolism and presence or absence of the mutation was examined in CAD patients. The frequency of this mutant allele in CAD patients was significantly higher than that of controls. The presence of this mutation was significantly associated with higher body mass index, but not with other plasma lipid and glucose levels in CAD patients. This mutation was associated with coronary heart disease and obesity but was not with glucose and lipid metabolism disorders in Japanese nationals.
在83例CAD患者和107例对照者（均为日本国民）中测量β3 - 肾上腺素能受体基因的突变频率，并比较两组的突变发生率。在CAD患者中研究脂质和葡萄糖代谢特征与突变存在与否之间的关系。CAD患者中这种突变等位基因的频率显著高于对照组。这种突变的存在与较高的体重指数显著相关，但与CAD患者的其他血浆脂质和葡萄糖水平无关。在日本国民中，这种突变与冠心病和肥胖相关，但与葡萄糖和脂质代谢紊乱无关。
