Punj V, Matta H, Kanwar S S
Department of Microbiology, College of Basic Sciences, Himachal Pradesh Agricultural University, Palampur, India.
Acta Microbiol Pol. 1996;45(3-4):261-7.
The intraperitoneal injection of Salmonella typhi into mice produced typhoid infection involving all the vital organs. Infection of liver was more persistent and progressive than in other organs. During the course of experimental infection, no humoral immune response was detected against phospholipase-A fractions upto 3 weeks after challenge, but significant cell mediated immunity (CMI) was found. Increased CMI response against protein antigens correlated well with the decreasing bacterial load, what suggested that CMI against proteins was important in pathogenesis of this disease.
给小鼠腹腔注射伤寒沙门氏菌会引发涉及所有重要器官的伤寒感染。肝脏感染比其他器官的感染更持久且呈进行性发展。在实验感染过程中，直到攻击后3周都未检测到针对磷脂酶 - A组分的体液免疫反应，但发现了显著的细胞介导免疫（CMI）。针对蛋白质抗原的CMI反应增强与细菌载量的降低密切相关，这表明针对蛋白质的CMI在该疾病的发病机制中很重要。
