Howden C W
Department of Internal Medicine, University of South Carolina School of Medicine, Columbia 29203-6808, USA.
Am J Gastroenterol. 1997 Apr;92(4 Suppl):17S-19S; discussion 19S-21S.
Clinical evidence supports the relationship between acid suppression and healing of duodenal ulceration and reflux esophagitis. In contrast to H2-receptor antagonists which suppress acid secretion by inhibiting the initial stimulation of the parietal cell, proton pump inhibitors directly inhibit hydrogen ion secretion and can, therefore, better provide the degree and duration of intragastric pH elevation necessary for the optimal management of duodenal ulceration and reflux esophagitis. Clinical studies have shown that proton pump inhibitors, such as omeprazole and lansoprazole, provide more rapid healing and higher healing rates for both duodenal ulcers and reflux esophagitis than do H2-receptor antagonists.
临床证据支持胃酸抑制与十二指肠溃疡愈合及反流性食管炎之间的关系。与通过抑制壁细胞的初始刺激来抑制胃酸分泌的H2受体拮抗剂不同，质子泵抑制剂直接抑制氢离子分泌，因此能够更好地提供十二指肠溃疡和反流性食管炎最佳治疗所需的胃内pH值升高的程度和持续时间。临床研究表明，奥美拉唑和兰索拉唑等质子泵抑制剂在治疗十二指肠溃疡和反流性食管炎方面，比H2受体拮抗剂能实现更快愈合且愈合率更高。
