Majno P E, Morel P, Mentha G
Département de Chirurgie, Hôpital Cantonal Universitaire, Genève.
Swiss Surg. 1995(4):182-5.
Tumor necrosis factor (TNF) is a powerful cytokine with an important role in the inflammatory acute phase response and in the activation of the immune system. It exerts its action through the adherence to cellular receptors, known as the TNF-R55 und TNF-R75. High levels of these receptors are present in the blood in a soluble form and binding circulating TNF can neutralise its systemic effects. Although the knowledge on the biology of TNF and TNF-sR is progressing rapidly, little is known on the action of this cytokine and of its soluble receptors in liver disease and liver transplantation. The literature on the subject is reviewed, and trends for future research are discussed.
肿瘤坏死因子（TNF）是一种强大的细胞因子，在炎症急性期反应和免疫系统激活中起重要作用。它通过与细胞受体（称为TNF-R55和TNF-R75）结合发挥作用。这些受体的高水平以可溶性形式存在于血液中，结合循环中的TNF可中和其全身效应。尽管关于TNF和TNF-sR生物学的知识进展迅速，但对于这种细胞因子及其可溶性受体在肝病和肝移植中的作用了解甚少。本文对该主题的文献进行了综述，并讨论了未来的研究趋势。
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