Azurin D J, Go L S, Kirkland M L
Department of Surgery, Pennsylvania Hospital, Philadelphia 19106, USA.
Am Surg. 1997 May;63(5):410-3.
Extensive extirpative resection of advanced head and neck tumors followed by functional reconstruction is a formidable undertaking. Poor long-term survival and substantial morbidity and mortality have often conferred a nihilistic approach toward these patients. We reviewed our experience with transhiatal gastric transposition with pharyngogastric anastomosis for reconstruction of pharyngoesophageal defects to assess the value of undertaking such a formidable surgical intervention. A retrospective analysis (1990-1994) of 20 consecutive patients with advanced head and neck tumors who underwent pharyngolaryngoesophagectomy followed by transhiatal gastric transposition with pharyngogastric anastomosis was performed. Morbidity was 35 per cent; mortality was 10 per cent. Pharyngogastric leaks occurred in 10 per cent of patients. The median postoperative stay was 19 days. Ninety-four per cent of patients had good to excellent palliation. Follow-up averaged 14.3 months. Late stricture occurred in two patients that was easily amenable to dilatation. Tumor recurrence caused dysphagia in one patient; otherwise, all patients are swallowing well or have died without dysphagia. Gastric transposition without thoracotomy is a versatile and reliable method for reconstruction of large pharyngoesophageal defects and is associated with an acceptable morbidity and mortality, thus allowing good palliation in a patient population with an extremely poor prognosis and an otherwise poor quality of life.
对晚期头颈部肿瘤进行广泛的根治性切除并随后进行功能重建是一项艰巨的任务。长期生存率低以及高发病率和死亡率常常使人们对这些患者采取消极的治疗方法。我们回顾了经裂孔胃转位并进行咽胃吻合术以重建咽食管缺损的经验,以评估进行这种艰巨手术干预的价值。对连续20例晚期头颈部肿瘤患者进行了回顾性分析(1990 - 1994年),这些患者接受了咽喉食管切除术,随后进行经裂孔胃转位并咽胃吻合术。发病率为35%;死亡率为10%。10%的患者发生了咽胃漏。术后中位住院时间为19天。94%的患者获得了良好至极佳的缓解。平均随访14.3个月。两名患者出现晚期狭窄,易于扩张治疗。一名患者因肿瘤复发导致吞咽困难;否则,所有患者吞咽良好或在未出现吞咽困难的情况下死亡。不开胸的胃转位是重建大的咽食管缺损的一种通用且可靠的方法,且发病率和死亡率可接受,从而能在预后极差且生活质量原本很低的患者群体中实现良好的缓解。