Gendelman R, Orzech Y, Mashiah P, Birenbaum M, Gazit A, Yaniv A
Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Israel.
J Gen Virol. 1997 Apr;78 ( Pt 4):801-5. doi: 10.1099/0022-1317-78-4-801.
Caprine arthritis-encephalitis virus (CAEV), an ungulate lentivirus, causes a natural infection in goats. The present report demonstrates that in vitro, CAEV infection is associated with apoptosis, characterized by morphological changes such as condensation of chromatin and the appearance of apoptotic bodies. The presence of DNA fragments was documented by the appearance of a DNA 'ladder' in agarose gel electrophoresis, as well as by in situ end-labelling of DNA ends. In addition, flow cytometric analyses revealed the presence of a hypodiploid peak that gradually appeared as virus infection progressed.
山羊关节炎-脑炎病毒（CAEV）是一种有蹄类慢病毒，可在山羊中引起自然感染。本报告表明，在体外，CAEV感染与细胞凋亡有关，其特征为染色质凝聚和凋亡小体出现等形态学变化。琼脂糖凝胶电泳中DNA“梯形条带”的出现以及DNA末端的原位末端标记证明了DNA片段的存在。此外，流式细胞术分析显示，随着病毒感染的进展，逐渐出现一个亚二倍体峰。
