Martínez-Frías M L, Frías J L, Bermejo E, Rodríguez-Pinilla E, Urioste M
ECEMC, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Am J Med Genet. 1997 May 2;70(1):16-23.
Since its description by Czeizel [1981: Am J Med Genet 10:25-35], there has been general acceptance of the schisis association as a distinct entity although, to the best of our knowledge, no other epidemiological study has confirmed its existence. Here we present an epidemiologic study on schisis defects and their associations with each other in children with and without blastogenetic defects. This study demonstrates that most cases represent the dysmorphogenetic response of the primary developmental field.
自Czeizel于1981年对其进行描述（《美国医学遗传学杂志》10:25 - 35）以来，尽管据我们所知没有其他流行病学研究证实其存在，但裂体关联作为一个独特的实体已被普遍接受。在此，我们展示了一项关于裂体缺陷及其在有和没有胚源性缺陷儿童中相互关联的流行病学研究。这项研究表明，大多数病例代表了主要发育领域的畸形发生反应。
