Ohm M, Juto J E, Andersson K, Bodin L
Department of Otorhinolaryngology, Söder Hospital, Karolinska Institute, Stockholm, Sweden.
Am J Rhinol. 1997 Mar-Apr;11(2):167-75. doi: 10.2500/105065897782537151.
Health problems associated with the indoor climate have aroused an increasing scientific interest, and the term "sick-building syndrome" (SBS), which describes the most frequent symptoms in this context, has been coined. However, it has been difficult to demonstrate objectively any pathophysiological changes in the subjects affected. Thirty-three healthy and nonatopic persons were randomly selected on the basis of answers in a postal questionnaire dealing with discomfort or health symptoms experienced in their home environment. Twenty-three lived in a residential area with indoor climate problems (SBS area) and 10 lived in an area without climate problems (non-SBS area). Twelve persons from the SBS area reported nasal symptoms, which they ascribed to their home environment. The remaining 11 persons from the same area, as well as the 10 subjects from the non-SBS area, had no nasal distress. They were examined with rhinostereometry during histamine provocation. Hyperreactivity, defined as mucosal swelling exceeding 0.4 mm at 5 and 10 minutes after provocation with 0.14 ml of 2 mg/ml histamine chloride, was frequent in the symptomatic SBS group as well as in the asymptomatic SBS group. The analysis of the increment of mucosal swelling for the whole range of histamine chloride concentrations (0.1 mg/ml to 16 mg/ml) showed significantly different growth curves for the three groups in the residential areas and an external reference group, (p < 0.0001). Subjects living in the SBS area were prone to nasal hyperreactivity, whether they reported symptoms from the upper airways or not. The results support the hypothesis that living in an SBS area increases the risk of developing nonspecific nasal hyperreactivity.
与室内环境相关的健康问题已引起越来越多的科学关注，“病态建筑综合征”（SBS）这一术语也应运而生，它描述了在此背景下最常见的症状。然而，很难客观地证明受影响人群存在任何病理生理变化。基于一份关于家庭环境中不适或健康症状的邮政调查问卷的回答，随机挑选了33名健康且无特应性的人。其中23人居住在存在室内环境问题的居民区（SBS区），10人居住在无环境问题的区域（非SBS区）。SBS区的12人报告有鼻部症状，并将其归因于家庭环境。来自同一区域的另外11人以及非SBS区的10名受试者没有鼻部不适。在组胺激发试验期间，对他们进行了鼻立体测量检查。超敏反应定义为在使用0.14 ml 2 mg/ml氯化组胺激发后5分钟和10分钟时黏膜肿胀超过0.4 mm，在有症状的SBS组和无症状的SBS组中都很常见。对整个氯化组胺浓度范围（0.1 mg/ml至16 mg/ml）内黏膜肿胀增加情况的分析显示，居民区的三组以及一个外部参照组的生长曲线存在显著差异（p < 0.0001）。无论是否报告有上呼吸道症状，居住在SBS区的受试者都容易出现鼻部超敏反应。这些结果支持了这样一种假设，即生活在SBS区会增加患非特异性鼻部超敏反应的风险。
