生理浓度的血管紧张素II对大鼠肠系膜动脉中去甲肾上腺素和钾离子升压作用的增强：前列腺素E2和皮质醇的影响

Potentiation of pressor effects of noradrenaline and potassium ions in the rat mesenteric arteries by physiological concentrations of angiotensin II: effects of prostaglandin E2 and cortisol.

Kondo K, Manku M S, Horrobin D F, Boucher R, Genest J

Clin Sci Mol Med. 1977 Sep;53(3):233-9. doi: 10.1042/cs0530233.

Abstract

In the perfused rat mesenteric vascular bed, the effects of angiotensin II, cortisol and prostaglandin E2 on the vascular responses to noradrenaline or potassium chloride were studied. 2. Angiotensin II in subpressor concentrations potentiated the vasoconstrictor response to noradrenaline and potassium chloride. This effect of angiotensin II was inhibited in the presence of indomethacin and prostaglandin E2. 3. Cortisol in physiological concentrations inhibited the potentiating effect of angiotensin II. 4. Prostaglandin E2 enhanced the vasoconstrictor response to noradrenaline. This effect was not abolished by cortisol. 5. These results suggest that some actions of angiotensin II and cortisol in vivo are mediated by the regulation of prostaglandin synthesis or release.

摘要

在灌注的大鼠肠系膜血管床中，研究了血管紧张素II、皮质醇和前列腺素E2对去甲肾上腺素或氯化钾引起的血管反应的影响。2. 低于升压浓度的血管紧张素II增强了对去甲肾上腺素和氯化钾的血管收缩反应。血管紧张素II的这种作用在吲哚美辛和前列腺素E2存在时受到抑制。3. 生理浓度的皮质醇抑制了血管紧张素II的增强作用。4. 前列腺素E2增强了对去甲肾上腺素的血管收缩反应。这种作用未被皮质醇消除。5. 这些结果表明，血管紧张素II和皮质醇在体内的某些作用是通过调节前列腺素的合成或释放介导的。