Simon H U
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos.
Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):206-8. doi: 10.1159/000237548.
Apoptosis is a necessary process to maintain correct cell numbers in a multicellular organism. Defects in this process may contribute to the pathogenesis of a number of human diseases. We have suggested that inhibition of apoptosis in eosinophils by cytokines such as IL-5 and GM-CSF may play an important role in the pathogenesis of allergic disorders. Here, we review our recent progress in understanding the processes regulating eosinophil apoptosis.
