Connors M H
Department of Pediatrics, University of California, Davis Medical Center, Sacramento, USA.
Pediatr Clin North Am. 1997 Apr;44(2):301-6. doi: 10.1016/s0031-3955(05)70478-8.
Insulin has an important role in the GH:IGF-I axis, and its absence leads to major endocrine disturbances, particularly during puberty. Rapid growth in the prediabetic phase occurs and may be a risk factor. Final height reflects gender and the age of onset more than specific growth factors. The influence of hepatic insulin on IGF-I bioactivity has important implications in diabetic adolescents.
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