Elkayam U, Rotmensch H H, Terdiman R, Geller E, Laniado S
Chest. 1977 Nov;72(5):623-7. doi: 10.1378/chest.72.5.623.
The intravenous administration of chlorpromazine in 12 patients with acute myocardial infarction and altered pump function was followed by a significant reduction in systemic vascular resistance (28.4%) and an increased cardiac index (23.0%). The drug also produced a significant decline in mean pulmonary capillary wedge pressure (38.2%), while the heart rate and mean stroke work index did not change significantly. Although the mean blood pressure decreased by 18.3%, the transymocardial pressure gradient was not affected. A significant reduction in the major determinants of myocardial oxygen consumption, such as arterial blood pressure and left ventricular wall tension, suggested a decrease in myocardial demand for oxygen. Improvement of left ventricular performance was associated with a sedative effect in most of the patients. Intravenous administration of chlorpromazine proved to be of benefit in patients with moderate to severe congestive heart failure and cardiogenic shock.
对12例急性心肌梗死且泵功能改变的患者静脉注射氯丙嗪后，全身血管阻力显著降低（28.4%），心脏指数增加（23.0%）。该药还使平均肺毛细血管楔压显著下降（38.2%），而心率和平均每搏功指数无明显变化。尽管平均血压下降了18.3%，但跨心肌压力梯度未受影响。心肌耗氧量的主要决定因素如动脉血压和左心室壁张力显著降低，提示心肌需氧量减少。左心室功能的改善在大多数患者中伴有镇静作用。静脉注射氯丙嗪对中度至重度充血性心力衰竭和心源性休克患者有益。
