Hirota S, Soejima T, Obayashi K, Hishikawa Y, Honda K, Okamoto Y, Maeda H, Takada Y, Inoue K, Kinishi M, Amatsu M, Kimura S
Department of Radiology, Hyogo Medical Center for Adults, Akashi, Japan.
Radiat Med. 1996 Nov-Dec;14(6):297-302.
From January 1984 to December 1993, 184 patients with previously untreated T1 and T2 (UICC 1987) laryngeal glottic cancer underwent radiotherapy at Hyogo Medical Center for Adults. The prognostic variables analyzed included sex, age, smoking index, T stage, tumor size, tumor type, gross anterior commissure involvement (gross ACI), histological differentiation, administered dose, TDF, overall treatment time, chemotherapy, initial response, and the dose required to achieve CR. Both univariate and multivariate analyses were performed. The T stage, tumor size, and gross ACI were significant variables in univariate analysis, while the tumor type and gross ACI were significant on multivariate analysis. The 5-year recurrence-free survival of patients with gross ACI was significantly worse than that of those without ACI (57.6% vs. 89.9%). Among gross ACI patients, the recurrence-free survival of those treated with 70-72 Gy was superior to that of those receiving 60-62 Gy, suggesting that at least 70 Gy was necessary to control such diseases.
1984年1月至1993年12月，184例初治的T1和T2期（UICC 1987）喉声门癌患者在兵库成人医疗中心接受了放射治疗。分析的预后变量包括性别、年龄、吸烟指数、T分期、肿瘤大小、肿瘤类型、大体前联合受累情况（大体ACI）、组织学分化程度、给予的剂量、TDF、总治疗时间、化疗、初始反应以及达到完全缓解所需的剂量。进行了单因素和多因素分析。T分期、肿瘤大小和大体ACI在单因素分析中是显著变量，而肿瘤类型和大体ACI在多因素分析中是显著变量。有大体ACI的患者5年无复发生存率显著低于无ACI的患者（57.6%对89.9%）。在有大体ACI的患者中，接受70 - 72 Gy治疗的患者无复发生存率优于接受60 - 62 Gy治疗的患者，这表明至少需要70 Gy来控制此类疾病。
