Düsing R, Kramer H J
Dtsch Med Wochenschr. 1977 Oct 28;102(43):1541-6. doi: 10.1055/s-0028-1105534.
In 36 patients with essential hypertension the action and side effects of hydrochlorothiazide (25 mg/d), hydrochlorothiazide-triamterene (25 and 50 mg/d) and propranolol (160 mg/d) were investigated. Hydrochlorothiazide and hydrochlorothiazide-triamterene led to an average decrease of the systolic blood pressure by 21 and 30 mm Hg and of the diastolic pressure by 11 and 18 mm Hg. Propranolol alone decreased the systolic pressure by 35 mm Hg on average in 8 out of 16 patients. The diastolic pressure was lowered by 20 mm Hg. In the remaining 8 patients the systolic pressure, when propranolol was used alone, decreased by 21.3 mm Hg, the diastolic pressure by 11.3 mm Hg. Addition of hydrochlorothiazide-triamterene lowered pressures by a further 22.5 (systolic) and 10.6 (diastolic) mm Hg. No disturbances of the potassium or acid-base balance were observed using hydrochlorothiazide-triamterene.
对36例原发性高血压患者研究了氢氯噻嗪（25毫克/天）、氢氯噻嗪-氨苯蝶啶（25和50毫克/天）及普萘洛尔（160毫克/天）的作用和副作用。氢氯噻嗪和氢氯噻嗪-氨苯蝶啶使收缩压平均分别下降21和30毫米汞柱，舒张压分别下降11和18毫米汞柱。单独使用普萘洛尔时，16例患者中有8例收缩压平均下降35毫米汞柱，舒张压下降20毫米汞柱。其余8例患者单独使用普萘洛尔时，收缩压下降21.3毫米汞柱，舒张压下降11.3毫米汞柱。加用氢氯噻嗪-氨苯蝶啶后，收缩压和舒张压又分别进一步下降22.5毫米汞柱和10.6毫米汞柱。使用氢氯噻嗪-氨苯蝶啶未观察到钾或酸碱平衡紊乱。
