Scherer R
Klinik für Anaesthesiologie und operative Intensivmedizin, Clemenshospital Münster.
Anaesthesist. 1997 Feb;46(2):81-90. doi: 10.1007/s001010050375.
Thermoregulation and its impairment by anaesthesia and surgery has recently been brought back into focus by researchers and clinicians. All volatile and IV anaesthetics, opioids, as well as spinal and epidural anaesthesia increase the inter-threshold range of thermoregulation from 0.2 degree C to 4 degrees C between vasodilation and vasoconstriction. Thermoregulatory vasoconstriction and shivering occurs in anaesthetized patients at lower core temperatures than in awake subjects. Following induction of general or spinal/epidural anaesthesia, core temperature decreases significantly due to internal redistribution of body heat from the core thermal compartment to peripheral tissues. About 1 h after induction of general anaesthesia and initial redistribution hypothermia, a real reduction in body heat occurs as heat loss exceeds metabolic heat production. Heat loss is further increased due to low operating room temperatures, evaporation from open body cavities, and cold IV fluids. Peripheral thermoregulatory vasoconstriction is triggered by core temperatures between 33 degrees C and 35 degrees C, and is able to slow heat loss. However, body heat content continues to decrease even though core temperatures remain nearly constant. During spinal or epidural anaesthesia thermoregulation remains intact in the unblocked body segments, leading to reduced real heat loss when compared to general anaesthesia. Inadvertent hypothermia markedly decreases drug metabolism. Coagulation is impaired by cold-induced defects of platelet function. Hypothermia reduces neutrophil phagocytosis and oxidative killing capacity, causing wound infections. Postoperative hypothermia represents an unnecessary stress for the circulatory system, elevating plasma catecholamines and leading to myocardial ischaemia and arrhythmias. These hypothermia-related morbidities therefore have consequences reaching fare into the postoperative period. Prevention of inadvertent hypothermia is always indicated. Forced-air warming is the most effective and safest method to prevent perioperative hypothermia.
近期,研究人员和临床医生重新关注了体温调节以及麻醉和手术对其造成的损害。所有挥发性和静脉麻醉剂、阿片类药物以及脊髓和硬膜外麻醉都会使体温调节的阈间范围从血管舒张和血管收缩之间的0.2摄氏度增加到4摄氏度。与清醒受试者相比,麻醉患者在较低的核心体温时就会出现体温调节性血管收缩和寒战。在全身或脊髓/硬膜外麻醉诱导后,由于身体热量从核心热区重新分布到外周组织,核心体温会显著下降。在全身麻醉诱导和初始再分布性体温过低约1小时后,随着热量散失超过代谢产热,身体热量会出现真正的减少。由于手术室温度低、开放体腔的蒸发以及冷的静脉输液,热量散失会进一步增加。外周体温调节性血管收缩由33摄氏度至35摄氏度之间的核心体温触发,能够减缓热量散失。然而,即使核心体温保持几乎恒定,身体热量含量仍会继续下降。在脊髓或硬膜外麻醉期间,未阻滞身体节段的体温调节功能保持完整,与全身麻醉相比,实际热量散失减少。意外体温过低会显著降低药物代谢。低温会因血小板功能的冷诱导缺陷而损害凝血功能。低温会降低中性粒细胞的吞噬作用和氧化杀伤能力,导致伤口感染。术后体温过低对循环系统来说是一种不必要的应激,会升高血浆儿茶酚胺水平,导致心肌缺血和心律失常。因此,这些与体温过低相关的发病率会对术后时期产生深远影响。始终需要预防意外体温过低。强制空气加温是预防围手术期体温过低最有效和最安全的方法。