视网膜神经节细胞短暂性和持续性抑制性甘氨酸能输入的划分
Partition of transient and sustained inhibitory glycinergic input to retinal ganglion cells.
作者信息
Han Y, Zhang J, Slaughter M M
机构信息
Department of Physiology, School of Medicine, State University of New York, Buffalo, New York 14214, USA.
出版信息
J Neurosci. 1997 May 15;17(10):3392-400. doi: 10.1523/JNEUROSCI.17-10-03392.1997.
Abstract
Physiological and pharmacological properties of possible subtypes of the native glycine receptor were investigated in retinal neurons using whole-cell voltage-clamp techniques. Two discrete inhibitory glycine responses were identified in ganglion cells. The responses could be distinguished pharmacologically: one was sensitive to strychnine and the other to 5,7-dichlorokynurenic acid. The two responses had different kinetics: the former had a fast onset and fast desensitization, whereas the latter had a slower onset and was much more sustained. The physiological and pharmacological distinctions suggest that the responses are mediated by different receptors. These receptors transduce glycinergic synaptic signals to ganglion cells, where they serve as low- and high-pass filters, respectively, of EPSPs.
摘要
利用全细胞膜片钳技术，在视网膜神经元中研究了天然甘氨酸受体可能的亚型的生理和药理特性。在神经节细胞中鉴定出两种不同的抑制性甘氨酸反应。这些反应在药理学上可以区分：一种对士的宁敏感，另一种对5,7-二氯犬尿氨酸敏感。这两种反应具有不同的动力学：前者起效快且脱敏快，而后者起效慢且持续时间长得多。生理和药理学上的差异表明，这些反应是由不同的受体介导的。这些受体将甘氨酸能突触信号转导至神经节细胞，在那里它们分别作为兴奋性突触后电位的低通和高通滤波器。
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