Palmer S M, Kanj S S, Davis R D, Tapson V F
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
Transplantation. 1997 Apr 27;63(8):1189-90. doi: 10.1097/00007890-199704270-00023.
Infection with Nocardia species is an increasingly recognized complication of solid organ transplantation. Nocardia asteroides accounts for most transplant-related nocardiosis, while Nocardia brasiliensis rarely causes infection in organ transplant recipients.
We describe a case of disseminated infection with N brasiliensis in a single-lung transplant recipient who also had concomitant infections with viral and fungal organisms.
Although the mortality rate is high in immunocompromised patients with disseminated Nocardia infection, our patient responded favorably to prolonged antimicrobial therapy.
This case illustrates that N brasiliensis, like N asteroides, produces pulmonary disease and dissemination in solid organ transplant recipients, and demonstrates the utility of prolonged treatment with trimethoprim-sulfamethoxazole in Nocardia infections.
诺卡菌属感染是实体器官移植中一种日益被认识到的并发症。星形诺卡菌是大多数与移植相关的诺卡菌病的病因，而巴西诺卡菌很少在器官移植受者中引起感染。
我们描述了一例单肺移植受者发生巴西诺卡菌播散性感染的病例，该患者同时还合并有病毒和真菌病原体感染。
尽管播散性诺卡菌感染的免疫功能低下患者死亡率很高，但我们的患者对延长的抗菌治疗反应良好。
该病例表明，巴西诺卡菌与星形诺卡菌一样，可在实体器官移植受者中引起肺部疾病和播散，并证明了甲氧苄啶-磺胺甲恶唑延长治疗在诺卡菌感染中的作用。
