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Water soluble derivatives and bifunctional analogs of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

作者信息

Fiebig H H, Eisenbrand G, Zeller W J, Deutsch-Wenzel T

出版信息

Eur J Cancer (1965). 1977 Sep;13(9):937-45. doi: 10.1016/0014-2964(77)90169-4.

DOI:10.1016/0014-2964(77)90169-4
PMID:913476
Abstract
摘要

相似文献

1
Water soluble derivatives and bifunctional analogs of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Eur J Cancer (1965). 1977 Sep;13(9):937-45. doi: 10.1016/0014-2964(77)90169-4.
2
Some new congeners of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Synthesis of bifunctional analogs and water soluble derivatives and preliminary evaluation of their chemotherapeutic potential.抗癌剂1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀）的一些新同系物。双功能类似物和水溶性衍生物的合成及其化疗潜力的初步评估。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Aug 30;86(3):279-86. doi: 10.1007/BF00286946.
3
Anticancer activity of new nitrosoureas against Walder carcinosarcoma 256 and DMBA-induced mammary cancer of the rat.
Oncology. 1980;37(3):177-83. doi: 10.1159/000225430.
4
Chemotherapeutic activity of new 2-chloroethylnitrosoureas in rat L5222 leukemia: comparison of bifunctional and water-soluble derivatives with 1,3-bis(2-chloroethyl)-1-nitrosourea.
J Natl Cancer Inst. 1978 Feb;60(2):345-8. doi: 10.1093/jnci/60.2.345.
5
Genetic effects of some new bifunctional and water-soluble analogs of the anti-cancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in Saccharomyces cerevisiae.
Mutat Res. 1977 Jan;42(1):45-50. doi: 10.1016/s0027-5107(77)80006-7.
6
Effect of 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea on experimental tumors.
Gan. 1977 Dec;68(6):819-24.
7
Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.鸟氨酸脱羧酶抑制剂α-二氟甲基鸟氨酸增强1,3-双(2-氯乙基)-1-亚硝基脲的抗肿瘤治疗效果
Cancer Res. 1981 Nov;41(11 Pt 1):4426-31.
8
The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma pharmacokinetics and biotransformation of BCNU.苯巴比妥预处理对1,3-双(2-氯乙基)-1-亚硝基脲(BCNU)、1-(2-氯乙基)-3-环己基-1-亚硝基脲(CCNU)和1-(2-氯乙基)-3-(2,6-二氧代-3-哌啶基)-1-亚硝基脲(PCNU)抗肿瘤活性的影响，以及对BCNU血浆药代动力学和生物转化的影响。
J Pharmacol Exp Ther. 1979 Jan;208(1):1-6.
9
Sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea of the EMT6 tumor in vivo as determined by both tumor volume response and in vitro plating assay.通过肿瘤体积反应和体外平板接种试验测定EMT6肿瘤在体内对1,3-双（2-氯乙基）-1-亚硝基脲和1-（2-氯乙基）-3-（4-甲基环己基）-1-亚硝基脲的敏感性。
Cancer Res. 1978 Aug;38(8):2395-400.
10
Antitumor activity of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride in a variety of experimental tumors.
Gan. 1978 Aug;69(4):545-8.

引用本文的文献

1
Antitumor activity of new nitrosoureas on Yoshida sarcoma ascites cells implanted into the colon wall of rats.新型亚硝基脲对植入大鼠结肠壁的吉田肉瘤腹水细胞的抗肿瘤活性。
J Cancer Res Clin Oncol. 1981;101(3):285-302. doi: 10.1007/BF00410114.
2
Therapeutic evaluation of five nitrosoureas in a human melanoma xenograft system.
Cancer Chemother Pharmacol. 1983;11(3):147-52. doi: 10.1007/BF00254194.
3
L1210 leukemia i.v. implanted as a model for testing short-chain nitrosourea analogs.将L1210白血病通过静脉注射植入作为测试短链亚硝基脲类似物的模型。
J Cancer Res Clin Oncol. 1986;111(1):31-4. doi: 10.1007/BF00402772.
4
Pharmacokinetics of fotemustine and BCNU in plasma, liver and tumor tissue of rats bearing two lines of Walker 256 carcinoma.
Cancer Chemother Pharmacol. 1991;28(4):293-7. doi: 10.1007/BF00685537.
5
New cancer chemotherapy drugs in Europe.
Cancer Chemother Pharmacol. 1978;1(1):5-13. doi: 10.1007/BF00253141.