Takeichi S, Tazawa M, Morooka M, Minowa S, Yasaki T
Department of Pediatrics, Fujita Health University School of Medicine, Aichi, Japan.
Nihon Jinzo Gakkai Shi. 1997 Mar;39(2):155-60.
We conducted a long-term follow-up study of 37 children with biopsy-proved minimal change nephrotic syndrome during a period of over 6 years from onset to adulthood. These patients were classified into 4 groups of 13 infrequent relapsers, 17 frequent relapsers, 3 non-responders and 4 no-relapsers according to the International Study of Kidney Disease in Children (ISKDC). All patients were treated with conventional prednisolone therapy. Two cases of infrequent relapsers, 7 cases of frequent relapsers and 1 case of non responders relapsed in adult life. Two cases of infrequent relapsers and 1 case of frequent relapsers relapsed in adult life after remission for 5 or more years. We concluded that minimal change nephrotic syndromes in childhood should be followed up over a long duration in adult life, evenly in cases with good steroid responsiveness.
我们对37例经活检证实为微小病变型肾病综合征的儿童进行了一项长期随访研究，随访时间超过6年，从发病直至成年。根据儿童肾脏病国际研究（ISKDC），这些患者被分为4组，分别为13例偶发复发者、17例频发复发者、3例无反应者和4例无复发者。所有患者均接受常规泼尼松龙治疗。2例偶发复发者、7例频发复发者和1例无反应者在成年后复发。2例偶发复发者和1例频发复发者在缓解5年或更长时间后于成年后复发。我们得出结论，儿童期微小病变型肾病综合征在成年后应进行长期随访，即使是对类固醇反应良好的病例也应如此。
