Fewell J E, Tang P A
Department of Physiology and Biophysics, University of Calgary Health Sciences Center, Alberta, Canada.
J Appl Physiol (1985). 1997 May;82(5):1406-10. doi: 10.1152/jappl.1997.82.5.1406.
Exposure of a rat to a novel environment (e.g., a simulated open field) induces a transient increase in body-core temperature, which is often called stress-induced hyperthermia. Although pregnancy is known to influence thermoregulatory control, its effect on stress-induced hyperthermia is unknown. Therefore, 24 Sprague-Dawley rats (8 nonpregnant and 16 pregnant) were studied to test the hypothesis that pregnancy would alter the development of stress-induced hyperthermia after exposure to a simulated open field. Body-core temperature index increased significantly after exposure to a simulated open field in nonpregnant and gestation day-10 rats but not in gestation day-15 and day-20 rats. Thus our data provide evidence that pregnancy influences the body-core temperature response of rats exposed to a simulated open field in a gestation-dependent fashion. The functional consequences as well as the mechanisms involved remain to be determined.
将大鼠置于新环境（如模拟旷场）中会使其体核温度短暂升高，这通常被称为应激性体温过高。虽然已知妊娠会影响体温调节控制，但其对应激性体温过高的影响尚不清楚。因此，研究了24只斯普拉格-道利大鼠（8只未怀孕和16只怀孕），以检验以下假设：妊娠会改变大鼠在暴露于模拟旷场后应激性体温过高的发展情况。未怀孕和妊娠第10天的大鼠在暴露于模拟旷场后体核温度指数显著升高，但妊娠第15天和第20天的大鼠则未出现这种情况。因此，我们的数据表明，妊娠以依赖妊娠阶段的方式影响暴露于模拟旷场的大鼠的体核温度反应。其功能后果以及涉及的机制仍有待确定。
