Rebec G V, Grabner C P, Johnson M, Pierce R C, Bardo M T
Department of Psychology, Indiana University, Bloomington 47405, U.S.A.
Neuroscience. 1997 Feb;76(3):707-14. doi: 10.1016/s0306-4522(96)00382-x.
Voltammetric recordings with electrochemically modified carbon-fiber electrodes were obtained from specific regions of the forebrain in rats given free-choice access to a novel environment. Entry into novelty increased the catechol signal in the medial prefrontal cortex and shell of the nucleus accumbens by more than 100%, but had no consistent effect in either the neostriatum or accumbal core. In both the medial prefrontal cortex and accumbal shell, moreover, the novelty-induced increase in catecholaminergic activity was detectable only during the initial entry into the novel compartment and did not reappear when animals returned to the familiar environment. These results support increasing evidence for a functional distinction between the accumbal core and shell, with the latter having been linked to brain reward mechanisms. The results also indicate that novelty activates, albeit very transiently, some of the same neurochemical systems believed to play a critical role in the reinforcing effects of certain drugs of abuse.
在可自由选择进入新环境的大鼠中，使用电化学修饰的碳纤维电极从前脑的特定区域获得伏安记录。进入新环境使内侧前额叶皮质和伏隔核壳中的儿茶酚信号增加了100%以上，但在新纹状体或伏隔核核心中没有一致的影响。此外，在内侧前额叶皮质和伏隔核壳中，只有在最初进入新隔室时才能检测到新奇诱导的儿茶酚胺能活性增加，当动物回到熟悉的环境时，这种增加不会再次出现。这些结果支持了越来越多的证据表明伏隔核核心和壳之间存在功能差异，后者与大脑奖励机制有关。结果还表明，新奇尽管非常短暂地激活了一些相同的神经化学系统，这些系统被认为在某些滥用药物的强化作用中起关键作用。
