van Oss C, van Ooyen A
Netherlands Institute for Brain Research, Amsterdam, The Netherlands.
J Theor Biol. 1997 Mar 21;185(2):263-80. doi: 10.1006/jtbi.1996.0361.
Empirical studies have demonstrated that electrical activity of the neuron can directly affect the outgrowth of its neurites. In this paper, the implications of activity-dependent neurite outgrowth are studied in a simple two-cell model, containing one excitatory and one inhibitory cell. We show that activity-dependent outgrowth in combination with the presence of inhibition can account for biostability. The attractors, which can be both point and limit cycle attractors, may be associated with "normal" and "pathological" end states of network development. A slight modification of the model makes it applicable also to a range of other activity-dependent processes in neurons, such as changes in the number of efficacy of receptors. The main results of the previous model are also found in the modified model.
实证研究表明，神经元的电活动可直接影响其神经突的生长。在本文中，我们在一个简单的双细胞模型（包含一个兴奋性细胞和一个抑制性细胞）中研究了活动依赖型神经突生长的影响。我们表明，活动依赖型生长与抑制的存在相结合可以解释生物稳定性。吸引子可以是点吸引子和极限环吸引子，可能与网络发育的“正常”和“病理”终态相关。对该模型进行轻微修改后，它也适用于神经元中一系列其他活动依赖型过程，如受体效能数量的变化。先前模型的主要结果在修改后的模型中也能找到。
