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接种狂犬病病毒的小鼠外周神经的超微结构

Ultrastructure of peripheral nerves of mice inoculated with rabies virus.

作者信息

Minguetti G, Negrão M M, Hayashi Y, de Freitas O T

出版信息

Arq Neuropsiquiatr. 1979 Jun;37(2):105-12. doi: 10.1590/s0004-282x1979000200001.

DOI:10.1590/s0004-282x1979000200001
PMID:91359
Abstract

Fourty adult female albino mice were inoculated in the right hind leg with rabies viruses of the street type. The mice were sacrificed with an interval of 24 hours each, starting in the next day after inoculation. From the 10th day ownwards the animals started presenting signs of paralysis, first on the leg where the viruses were inoculated anbnormalities were found in peripheral nerves compatible with axonal degeneration with secondary demyelination but the rabies viruses were not found in the axoplasm, myelin sheet, Schwann cell cytoplasm, endoneural or in the epineural structures.

摘要

四十只成年雌性白化小鼠在右后腿接种街毒株狂犬病病毒。接种后次日开始,每隔24小时处死一只小鼠。从第10天起,动物开始出现麻痹症状,首先出现在接种病毒的腿部,外周神经出现与轴突变性伴继发性脱髓鞘相符的异常,但在轴浆、髓鞘、施万细胞胞质、神经内膜或神经外膜结构中均未发现狂犬病病毒。

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Ultrastructure of peripheral nerves of mice inoculated with rabies virus.接种狂犬病病毒的小鼠外周神经的超微结构
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引用本文的文献

1
Neuroglia infection by rabies virus after anterograde virus spread in peripheral neurons.狂犬病毒经外周神经元逆行播散后感染神经胶质细胞。
Acta Neuropathol Commun. 2020 Nov 23;8(1):199. doi: 10.1186/s40478-020-01074-6.