McNeill H, Yang C H, Brodsky M, Ungos J, Simon M A
Department of Biological Sciences, Stanford University, California 94305, USA.
Genes Dev. 1997 Apr 15;11(8):1073-82. doi: 10.1101/gad.11.8.1073.
The Drosophila eye is composed of dorsal and ventral mirror-image fields of opposite chiral forms of ommatidia. The boundary between these fields is known as the equator. We describe a novel gene, mirror (mrr), which is expressed in the dorsal half of the eye and plays a key role in forming the equator. Ectopic equators can be generated by juxtaposing mrr expressing and nonexpressing cells, and the path of the normal equator can be altered by changing the domain of mrr expression. These observations suggest that mrr is a key component in defining the dorsal-ventral boundary of tissue polarity in the eye. In addition, loss of mrr function leads to embryonic lethality and segmental defects, and its expression pattern suggests that it may also act to define segmental borders. Mirror is a member of the class of homeoproteins defined by the human proto-oncogene PBX1. mrr is similar to the Iroquois genes ara and caup and is located adjacent to them in this recently described homeotic cluster.
果蝇的眼睛由小眼的相反手性形式的背侧和腹侧镜像区域组成。这些区域之间的边界称为赤道。我们描述了一个新基因，镜像（mrr），它在眼睛的背侧半部表达，并在形成赤道中起关键作用。通过并列表达和不表达mrr的细胞可以产生异位赤道，并且通过改变mrr表达的区域可以改变正常赤道的路径。这些观察结果表明，mrr是定义眼睛组织极性背腹边界的关键成分。此外，mrr功能丧失会导致胚胎致死和节段缺陷，其表达模式表明它也可能在定义节段边界中起作用。镜像蛋白是由人类原癌基因PBX1定义的同源蛋白家族的成员。mrr与Iroquois基因ara和caup相似，并且在这个最近描述的同源异型簇中与它们相邻。
