Kim S J, Shiba E, Taguchi T, Watanabe T, Tanji Y, Kimoto Y, Izukura M, Takai S I
Department of Surgical Oncology, Osaka University Medical School, Japan.
Anticancer Res. 1997 Mar-Apr;17(2B):1373-8.
There have been many reports that the u-PA system plays an important role in cancer invasion and metastasis. The binding of u-PA to its specific cell-surface receptor, u-PAR, is necessary for the activation of u-PA system. The aim of this study is to evaluate the role and the prognostic value of u-PAR in cancer invasion and metastasis.
u-PAR expression in 104 breast cancers was investigated immunohistochemically using a monoclonal antibody against u-PAR.
u-PAR expression was mainly observed both on cancer cells and stromal cells. Patients with high u-PAR expression in cancer cells or stromal cells had a high relapse rate compared with patients with low u-PAR expression by the Kaplan-Meier method (p = 0.035 and 0.011, respectively). In uni- and multivariate analysis, u-PAR expression in stromal cells was significantly correlated with relapse (p = 0.017 and 0.043, respectively).
This study has shown that not only cancer cells but also stromal cells have an important roles in breast cancer invasion and metastasis, and that u-PAR expression in cancer cells and stromal cells might be a novel prognostic factor in breast cancer.
已有许多报道称尿激酶型纤溶酶原激活物（u-PA）系统在癌症侵袭和转移中起重要作用。u-PA与其特异性细胞表面受体u-PAR的结合是u-PA系统激活所必需的。本研究的目的是评估u-PAR在癌症侵袭和转移中的作用及预后价值。
使用抗u-PAR单克隆抗体，通过免疫组织化学方法研究104例乳腺癌中u-PAR的表达情况。
u-PAR表达主要见于癌细胞和基质细胞。采用Kaplan-Meier法分析，癌细胞或基质细胞中u-PAR高表达的患者与u-PAR低表达的患者相比，复发率更高（分别为p = 0.035和0.011）。在单因素和多因素分析中，基质细胞中u-PAR表达与复发显著相关（分别为p = 0.017和0.043）。
本研究表明，不仅癌细胞，而且基质细胞在乳腺癌侵袭和转移中都起重要作用，并且癌细胞和基质细胞中u-PAR的表达可能是乳腺癌一种新的预后因素。
